Preprint

• Relovska, S.*, Wang, H.*, Zhang, X., Fernandez-Tussy, P., Jeong, K.J., Choi, J., Suarez, Y., McDonald J.G., Ferdandez-Hernando, C., Chung, J-.J. DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time. bioRxiv doi: https://doi.org/10.1101/2023.21.572851

2023

• Hwang, J.Y.*, Chai, P.*, Nawaz, S.*, Choi, J., Lopez-Giraldez, F., Hussain, S., Bilguvar, K., Mane, S., Lifton, R.P., Ahmad, W., Zhang, K., Chung, J-.J.. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. eLife. 2023. doi: https://doi.org/10.7554/eLife.90095.2

• Huang, X., Miyata, H., Wang, H., Mori, G., Iida-Norita, R., Ikawa, M., Percudani, R., Chung, J-.J.. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Proc Natl Acad Sci U S A. 120 (39) doi:https://doi.org/10.1073/pnas.2304409120

• Hwang, J.Y., Chung, J.J. CATSPER Calcium Channels: twenty years on. Physiology (Bethesda). 2022 Dec 13. Epub ahead of print. PMID: 36512352. https://doi.org/10.1152/physiol.00028.2022

  2022

• Griffin, K.N.*, Li, H.*, Walters, B.W.*, Wang, H., Kaya, C.B., Kanyo, J., Lam, T., Cox, A.L., Chung, J-.J., Lesch, B.J. A nuclear role for the Argonaute protein AGO2 in mammalian gametogenesis. Genome Res. (2022) doi: 10.1101/gr.276578.122. https://genome.cshlp.org/content/32/9/1655.long

• Dou, Q., Turanov, A.A., Mariotti, M., Hwang, J., Wang, H., Lee, S.-G., Paulo, J.A., Yim, S.H., Gygi, S.P., Chung, J-.J., Gladyshev, V.N. Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. J Biol Chem (2022) DOI:https://doi.org/10.1016/j.jbc.2022.102183

• Zhao, Y.*, Wang, H.*, Wiesehoefer C., Shah N., Reetz E., Hwang J., Huang X., Lishko P., Davies K., Wennemuth G., Nicastro D.+, Chung, J-.J.+ 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nat Commun https://www.nature.com/articles/s41467-022-31050-8 +Co-correspondence

• Wang, H., Dou, Q., Jung, K., Choi, J., Gladyshev, V.N., Chung, J-.J. Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice. J Biol Chem (2022) DOI:https://doi.org/10.1016/j.jbc.2022.102077

• Wiesehofer, C., Wiesehofer, M., Dankert, J.T., Chung, J-.J., von Ostau, N.E., Singer, B.B., Wennemuth, G. CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm. FASEB J (2022) DOI:https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202101656RR

• Hwang, J., Wang, H., Lu, Y., Ikawa, M., Chung, J.J. C2cd6-encoded CatSpert Targets Sperm Calcium Channel to Ca2+ Signaling Domains in the Flagellar Membrane. Cell Reports DOI:https://doi.org/10.1016/j.celrep.2021.110226

  2021

• Wang, H. and Chung, J-.J. Mitochondria-cytoskeleton interactions in mammalian sperm revealed by cryoelectron tomogrphy. Proc Natl Acad Sci USA 2021 10.1073/pnas.2118020118

• Ded, L. and Chung, J-.J.  Collection of in vivo capacitated sperm by microdissection (2021) Bio-Protocols 11 (20) DOI: 10.21769/BioProtoc.4193

• Hwang, J., Maziarz, J., Wagner, G.P., Chung, J-.J. Molecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum. Cells 2021, 10(5), 1047; https://doi.org/10.3390/cells10051047

• Hwang, J.*, Nawaz, S.*, Choi, J.*, Wang, H., Hussain, S., Nawaz, M., Lopez-Giraldez, F., Jung, K.J., Dong, W., Oh, J., Bilguvar, K., Mane, S., Lee, C., Bystroff, C., Lifton, R., Ahmad, W. and Chung, J-.J. Genetic defects in DNAH2 underlie male infertility with multiple morphological abnormalities of the sperm flagella in humans and mice. Front. Cell Dev. Biol. (2021) DOI: 10.3389/fcell.2021.662903

  2020

• Ded, L., Hwang J., Miki, K. Shi, H.F., Chung, J-.J. 3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice, eLife (2020) DOI:10.7554/eLife.62043

• Wang, H., McGoldrick, L.L., and Chung, J-.J. Sperm Ion Channels and Transporters in Male Fertility and Infertility. Nature Reviews Urology (2020) DOI:10.1038/s41585-020-00390-9

• McGoldrick, L.L., and Chung, J-.J. Contraception: Stopping sperm in their tracks, eLife (2020). DOI:10.7554/eLife.55396

  2019

• Hwang, J., Mannowetz, N., Zhang, Y., Everley, R.A., Gygi, S.P., Bewersdorf, J., Lishko, P.V., and Chung, J-.J. (2019) Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility, Cell, https://doi.org/10.1016/j.cell.2019.03.047.

  2017

• Hwang, J. and Chung, J-.J. (2017) Sex at Atomic Resolution, Cell, http://dx.doi.org/10.1016/j.cell.2017.05.043

• Chung, J.J.+, Miki, K., Kim, D., Shim, S.H., Shi, H.F., Hwang, J.Y., Cai, X., Iseri, Y., Zhuang, X., and Clapham, D.E.+ (2017) CatSperz Regulates the Structural Continuity of Sperm Ca2+ Signaling Domains and is Required for Normal Fertility. eLife 2017;10.7554/eLife.23082 [Epub ahead] +Co-correspondence

  2016

• Chung, J-.J. (2016) Sugarcoated sperm. Mol Reprod Dev. Sep 3. [Epub ahead] dos:10.1002/mrd.22732.

• Chung, J-.J. (2016) Sperm flagellar Ca2+ signaling domains. Mol Reprod Dev. 83 (4):275. dos:10.1002/mrd.22628

  Before Joining Yale

• Chung, J-.J.*, Shim, S.H.*, Everley, R.A. Gygi, S.P. Zhuang, X., and Clapham, D.E. (2014) Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell 157 (4): 808-822. (*Equal contribution) (Selected for PaperFlicks; Cell video abstract online, Recommended by Faculty of 1000)

• Lishko, P., Kirichok, Y., Ren, D., Navarro, B., Chung, J-.J., and Clapham, D.E. (2012) The control of male fertility by spermatozoan ion channels. Ann. Rev. of Physiol. 74: 453-470.

• Chung, J-.J., Navarro, B., Krapivinsky, G., Krapivinsky, L., and Clapham, D.E. (2011) A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun 2: 153 doi:10.1038/ncomms1153.

• Chung, J.J., Okamoto, Y., Coblitz, B., Li, M., Qiu, Y., and Shikano, S. (2009) PI3K/Akt signaling-mediated surface expression sensed by 14-3-3 interacting motif. FEBS Let. 276 (19): 5547-58.

• Navarro, B., Kirichok, Y., Chung, J.J., and Clapham, D.E. (2008) Ion channels that control fertility in mammalian spermatozoa Int. J. Dev. Biol. 52: 607-613.

• Chung, J-.J. and Li, M. (2005) Biochemical characterization of the native Kv2.1 potassium channel. FEBS J. 272 (14): 3743-55.

• Chung, J-.J., Yang, H., and Li M. (2003) Genome-wide Analyses of Carboxyl-terminal Sequences. Mol Cell Proteomics 2(3): 173-81.

• Chung, J-.J., Shikano, S., Hanyu, Y., and Li, M. (2002) Functional diversity of protein C-termini: more than zipcoding? Trends Cell Biol. 12(3):146-50.

• Cho, S., Chung, J-.J., Choe, Y., Choi, H.S., Kim D.H., Rhee, K., and Kim, K. (2001) A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene. Brain Res Mol Brain Res. 87(2): 204-13.

• Cho, S., Chung, J-.J., Han J., Lee B.J., Kim D. H., Rhee K., and Kim K. (2001) 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via promoter region and that is distinct from all-trans-retinoic acid response element. Brain Res Mol Brain Res. 87(2): 214-22.

• Chung, J-.J., Cho, S., Kwon, Y.K., Kim, D.H., and Kim, K. (2000) Activation of retinoic acid receptor gamma induces proliferation of immortalized hippocampal progenitor cells. Brain Res Mol Brain Res. 83(1-2): 52-62.

• Francis, P.*, Chung, J-.J.*, Yasui, M., Berry, V., Moore, A., Wyatt, M.K., Wistow, G., Bhattacharya, S.S., and Agre, P. (2000) Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum Mol Genet. 9(15): 2329-34. (*Equal contribution)